In EverymanHYBRID the Hamsa has been seen in three places. Damsel posted a photo to her blog of small ceramic tiles that bore the symbols, with the caption "Thinking of hanging these around the place. I hope they… work?"
Most importantly, Jeff gave Jessa a hamsa necklace during the 7/24 UStream which has become an important symbol to him during the time that she has been missing. When Jeff found the necklace during Centralia he took it as confirmation that Jessa is dead. During the first Trial of The Seven Trials Of Habit Jeff buried Jessa's hamsa "near an old viaduct where [they] went to a picnic one time."
Despite its intended use, the hamsa has shown no effectiveness against the evil the cast is fighting against.